Pub. Date : 2008 Dec
PMID : 18951945
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, among the pathways examined, blockade of ERK function inhibited naringin-dependent p21WAF1 expression, reversed naringin-mediated inhibition of cell proliferation and decreased cell cycle proteins. | naringin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | However, the exact molecular mechanisms underlying the roles of integrated cell cycle regulation and MAPK signaling pathways in the regulation of naringin-induced inhibition of cell proliferation in vascular smooth muscle cells (VSMCs) remain to be identified. | naringin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Transfection of cells with dominant negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression. | naringin | zinc fingers and homeoboxes 2 | Homo sapiens |
| 4 | Transfection of cells with dominant negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression. | naringin | zinc fingers and homeoboxes 2 | Homo sapiens |
| 5 | Transfection of cells with dominant negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression. | naringin | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | Finally, naringin-induced reduction in cell proliferation and cell cycle protein was abolished in the presence of RasN17 and RafS621A mutant genes. | naringin | zinc fingers and homeoboxes 2 | Homo sapiens |