Title : Reduction of asymmetric dimethylarginine in the protective effects of rutaecarpine on gastric mucosal injury.

Pub. Date : 2008 Oct

PMID : 18841172






4 Functional Relationships(s)
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1 The in vitro effect of rutaecarpine on the release of calcitonin gene-related peptide (CGRP) and NO from isolated gastric tissues was also determined. rutecarpine calcitonin-related polypeptide alpha Rattus norvegicus
2 The in vitro effect of rutaecarpine on the release of calcitonin gene-related peptide (CGRP) and NO from isolated gastric tissues was also determined. rutecarpine calcitonin-related polypeptide alpha Rattus norvegicus
3 In the isolated gastric tissues, rutaecarpine significantly increased the release of both CGRP and NO; the release of NO, but not CGRP, was abolished in the presence of l-NAME (10(-4) mol/L). rutecarpine calcitonin-related polypeptide alpha Rattus norvegicus
4 The present results suggest that rutaecarpine protects the gastric mucosa against injury induced by ethanol and that the gastroprotection of rutaecarpine is related to reduction of ADMA levels through stimulating the release of CGRP. rutecarpine calcitonin-related polypeptide alpha Rattus norvegicus