Title : Induction of the nuclear proto-oncogene c-fos by the phorbol ester TPA and v-H-Ras.

Pub. Date : 2008 Nov 30

PMID : 18719353






2 Functional Relationships(s)
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1 Dominant-negative RhoA and Rac1 (but not Cdc42Hs) inhibited the TPA-Ras synergy by blocking the Ras-Rho-SRF signaling pathway. Tetradecanoylphorbol Acetate serum response factor Mus musculus
2 These results suggest that the activation of two distinct pathways such as Ras-Raf-ERK-TCF pathway and Rho-SRF pathway are responsible for the induction of c-fos by TPA and Ras in mitogenic signaling pathways. Tetradecanoylphorbol Acetate serum response factor Mus musculus