Title : Age-related differences in hepatic drug clearance in children: studies with lorazepam and antipyrine.

Pub. Date : 1991 Aug

PMID : 1868674






1 Functional Relationships(s)
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1 In contrast, lorazepam total clearance (CL) and unbound clearance (CLu) normalized to body weight were not significantly different between children and adults but were smaller in children when normalized to body surface area (CL = 31.9 versus 40.6 ml/min/m2, p = 0.036; CLu = 352 versus 485 ml/min/m2, p = 0.010). Lorazepam clusterin Homo sapiens