Pub. Date : 2008 Dec
PMID : 18682608
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity. | Cholesterol | sterol regulatory element binding factor 2 | Mus musculus |
| 2 | Diabetes in TgRIP-SREBP-2 mice was primarily due to defects in glucose- and potassium-stimulated insulin secretion as determined by glucose tolerance test. | Glucose | sterol regulatory element binding factor 2 | Mus musculus |
| 3 | Diabetes in TgRIP-SREBP-2 mice was primarily due to defects in glucose- and potassium-stimulated insulin secretion as determined by glucose tolerance test. | Potassium | sterol regulatory element binding factor 2 | Mus musculus |
| 4 | Diabetes in TgRIP-SREBP-2 mice was primarily due to defects in glucose- and potassium-stimulated insulin secretion as determined by glucose tolerance test. | Glucose | sterol regulatory element binding factor 2 | Mus musculus |
| 5 | SREBP-2-expressing islets also contained increased esterified cholesterol and unchanged triglycerides with reduced ATP levels. | Cholesterol | sterol regulatory element binding factor 2 | Mus musculus |
| 6 | SREBP-2-expressing islets also contained increased esterified cholesterol and unchanged triglycerides with reduced ATP levels. | Adenosine Triphosphate | sterol regulatory element binding factor 2 | Mus musculus |
| 7 | Taken together, these results indicate that activation of SREBP-2 in beta-cells caused severe diabetes by loss of beta-cell mass with accumulation of cholesterol, providing a new lipotoxic model and a potential link of disturbed cholesterol metabolism to impairment of beta-cell function. | Cholesterol | sterol regulatory element binding factor 2 | Mus musculus |
| 8 | Taken together, these results indicate that activation of SREBP-2 in beta-cells caused severe diabetes by loss of beta-cell mass with accumulation of cholesterol, providing a new lipotoxic model and a potential link of disturbed cholesterol metabolism to impairment of beta-cell function. | Cholesterol | sterol regulatory element binding factor 2 | Mus musculus |