Protein Name sterol regulatory element binding factor 2
Organism Mus musculus
Gene ID 20788
Gene Symbol

Srebf2

UniProt Q3U1N2 (SRBP2_MOUSE)
Relationships Total Number of functionally related compound(s) : 132
Total Number of Articles : 242
Description

sterol regulatory element binding factor 2

Gene Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in positive regulation of cholesterol biosynthetic process; positive regulation of miRNA transcription; and positive regulation of myelination. Acts upstream of or within cholesterol homeostasis and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; membrane; and nucleus. Is expressed in several structures, including 1st branchial arch; genitourinary system; limb; nervous system; and retina. Human ortholog(s) of this gene implicated in carotid artery disease; diabetes mellitus (multiple); prostate cancer; sarcoma; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • sterol regulatory element-binding protein 2
  • sterol regulatory element-binding transcription factor 2
  • SREBP-2
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Properties