Title : Negative inotropic effect of rapamycin on isolated human cardiomyocytes.

Pub. Date : 2008 Jul-Aug

PMID : 18652778






2 Functional Relationships(s)
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1 The acute negative inotropic effect of rapamycin on human cardiomyocytes might be due to altered calcium homeostasis through the binding of rapamycin to FKBP12.6 and its regulatory function on the ryanodine receptor, with increased calcium leakage from the sarcoplasmic reticulum. Calcium FKBP prolyl isomerase 1B Homo sapiens
2 The acute negative inotropic effect of rapamycin on human cardiomyocytes might be due to altered calcium homeostasis through the binding of rapamycin to FKBP12.6 and its regulatory function on the ryanodine receptor, with increased calcium leakage from the sarcoplasmic reticulum. Calcium FKBP prolyl isomerase 1B Homo sapiens