Title : Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

Pub. Date : 2008 Jul

PMID : 18598963






2 Functional Relationships(s)
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1 AF episodes were inducible in 81% of FKBP12.6-/-, but in only 7% of WT mice (P <.05), and were prevented by tetracaine in all FKBP12.6-/- mice. Tetracaine FK506 binding protein 1b Mus musculus
2 SR Ca(2+) leak in FKBP12.6-/- myocytes was 53% larger than in WT myocytes, and FKBP12.6-/- myocytes showed increased incidence of spontaneous SR Ca(2+) release events, which could be blocked by tetracaine. Tetracaine FK506 binding protein 1b Mus musculus