Pub. Date : 2008 Jul
PMID : 18591768
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1. | PQQ Cofactor | Parkinsonism associated deglycase | Homo sapiens |
| 2 | In this study, the expression level and oxidation status of DJ-1 were examined in SHSY-5Y cells and primary cultured neurons treated with 6-hydroxydopamine (6-OHDA) or H(2)O(2) in the presence or absence of PQQ. | PQQ Cofactor | Parkinsonism associated deglycase | Homo sapiens |
| 3 | The pI shift of DJ-1 to an acidic point, which was observed in SHSY-5Y cells treated with 6-OHDA, was inhibited by PQQ. | PQQ Cofactor | Parkinsonism associated deglycase | Homo sapiens |
| 4 | TOF-MS analyses showed that while the level of a reduced form of DJ-1, one of the active forms of DJ-1, was decreased in SHSY-5Y cells treated with 6-OHDA or H(2)O(2), PQQ increased the level of the reduced form of DJ-1. | PQQ Cofactor | Parkinsonism associated deglycase | Homo sapiens |
| 5 | TOF-MS analyses showed that while the level of a reduced form of DJ-1, one of the active forms of DJ-1, was decreased in SHSY-5Y cells treated with 6-OHDA or H(2)O(2), PQQ increased the level of the reduced form of DJ-1. | PQQ Cofactor | Parkinsonism associated deglycase | Homo sapiens |
| 6 | TOF-MS analyses showed that while the level of a reduced form of DJ-1, one of the active forms of DJ-1, was decreased in SHSY-5Y cells treated with 6-OHDA or H(2)O(2), PQQ increased the level of the reduced form of DJ-1. | PQQ Cofactor | Parkinsonism associated deglycase | Homo sapiens |
| 7 | These results suggest that PQQ prevents oxidative stress-induced changes in oxidative status of DJ-1. | PQQ Cofactor | Parkinsonism associated deglycase | Homo sapiens |
| 8 | Therefore, the neuroprotective effects of PQQ on oxidative stress-induced neuronal death may be at least in part involved in increased level of an active form of DJ-1. | PQQ Cofactor | Parkinsonism associated deglycase | Homo sapiens |