Pub. Date : 2008 Oct
PMID : 18515471
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hypotonicity reduces the activity of murine aquaporin-2 promoter induced by dibutyryl cAMP. | Bucladesine | aquaporin 2 | Mus musculus |
| 2 | When the cells were co-transfected with the construct containing more than 1.1 kb of the 5"-flanking region of murine AQP-2 gene (-9.5AQP2, -6.1AQP2 and -1.1AQP2) and the AQP-2 gene, 24 h exposure to 5 micromol l(-1) dibutyryl cAMP (DBcAMP) significantly increased the Luc activity by 2.3-fold in the isotonic medium (300 mosmol kg(-1)). | Cyclic AMP | aquaporin 2 | Mus musculus |
| 3 | When the cells were co-transfected with the construct containing more than 1.1 kb of the 5"-flanking region of murine AQP-2 gene (-9.5AQP2, -6.1AQP2 and -1.1AQP2) and the AQP-2 gene, 24 h exposure to 5 micromol l(-1) dibutyryl cAMP (DBcAMP) significantly increased the Luc activity by 2.3-fold in the isotonic medium (300 mosmol kg(-1)). | Bucladesine | aquaporin 2 | Mus musculus |
| 4 | These findings may indicate that hypotonicity reduces the cAMP-induced AQP-2 promoter activity mediated via TonE by activating JNK kinase. | Cyclic AMP | aquaporin 2 | Mus musculus |