Title : Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases.

Pub. Date : 2008 Aug

PMID : 18492726






5 Functional Relationships(s)
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Protein Name
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1 By treating cancer cell lines with 5-aza-2"-deoxycytidine (5-aza) and trichostatin A (TSA), we were able to restore MUC4 expression in a cell-specific manner. Decitabine mucin 4, cell surface associated Homo sapiens
2 By treating cancer cell lines with 5-aza-2"-deoxycytidine (5-aza) and trichostatin A (TSA), we were able to restore MUC4 expression in a cell-specific manner. Azacitidine mucin 4, cell surface associated Homo sapiens
3 By treating cancer cell lines with 5-aza-2"-deoxycytidine (5-aza) and trichostatin A (TSA), we were able to restore MUC4 expression in a cell-specific manner. trichostatin A mucin 4, cell surface associated Homo sapiens
4 By treating cancer cell lines with 5-aza-2"-deoxycytidine (5-aza) and trichostatin A (TSA), we were able to restore MUC4 expression in a cell-specific manner. trichostatin A mucin 4, cell surface associated Homo sapiens
5 Moreover, inhibition of histone deacetylation by TSA was associated with strong MUC4 repression in high-expressing cells. trichostatin A mucin 4, cell surface associated Homo sapiens