Pub. Date : 2008 Jun 18
PMID : 18486118
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We tested the hypothesis that uncompetitive NMDAR blockade with memantine prevents mitochondrial dysfunction-related neurodegeneration in vivo, using a mouse model of retinal ganglion cell layer (GCL) degeneration induced by rotenone, a mitochondrial complex I inhibitor. | Memantine | glutamate receptor, ionotropic, NMDA1 (zeta 1) | Mus musculus |
| 2 | Rotenone induced an increase in cell death and oxidative stress in GCL compared to controls, and these changes were prevented by the co-administration of memantine. | Memantine | germ cell-less, spermatogenesis associated 1 | Mus musculus |