Pub. Date : 2008 Jul 11
PMID : 18466757
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FKBP12.6(-/-) mice showed glucose intolerance coupled to insufficient insulin secretion upon a glucose challenge. | Glucose | FK506 binding protein 1b | Mus musculus |
| 2 | FKBP12.6(-/-) mice showed glucose intolerance coupled to insufficient insulin secretion upon a glucose challenge. | Glucose | FK506 binding protein 1b | Mus musculus |
| 3 | Insulin secretion in response to glucose was markedly impaired in FKBP12.6(-/-) islets, while sulfonylurea- or KCl-induced insulin secretion was unaffected. | Glucose | FK506 binding protein 1b | Mus musculus |
| 4 | These results indicate that FKBP12.6 plays a role in glucose-induced insulin secretion downstream of ATP production, independently of ATP-sensitive K(+) channels, in pancreatic beta-cells. | Adenosine Triphosphate | FK506 binding protein 1b | Mus musculus |