Pub. Date : 2008 Apr 23
PMID : 18434534
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. | Memantine | caspase 3 | Homo sapiens |
| 2 | Memantine (4 microM) inhibited isoflurane-induced elevations in cytosolic calcium levels and attenuated isoflurane-induced caspase-3 activation, apoptosis, and cell viability. | Memantine | caspase 3 | Homo sapiens |
| 3 | We also show for the first time that the NMDA receptor partial antagonist, memantine, can prevent isoflurane-induced caspase-3 activation and apoptosis in vivo and in vitro. | Memantine | caspase 3 | Homo sapiens |