Pub. Date : 2008 May
PMID : 18431519
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity. | kinetin riboside | cyclin D2 | Homo sapiens |
| 2 | By screening a chemical library using a cell-based assay for inhibition of CCND2 trans-activation, we identified the plant cytokinin kinetin riboside as an inhibitor of CCND2 trans-activation. | riboside | cyclin D2 | Homo sapiens |
| 3 | By screening a chemical library using a cell-based assay for inhibition of CCND2 trans-activation, we identified the plant cytokinin kinetin riboside as an inhibitor of CCND2 trans-activation. | riboside | cyclin D2 | Homo sapiens |
| 4 | Mechanistically, kinetin riboside upregulated expression of transcription repressor isoforms of cAMP-response element modulator (CREM) and blocked both trans-activation of CCND2 by various myeloma oncogenes and cis-activation of translocated CCND1, suggesting induction of an overriding repressor activity that blocks multiple oncogenic pathways targeting cyclin D genes. | riboside | cyclin D2 | Homo sapiens |