Pub. Date : 2008 Jun
PMID : 18340006
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS AND RESULTS: CYP2C9 overexpression as well as stimulation with 11,12-EET (up to 48 hours) time-dependently increased EphB4 expression in endothelial cells. | 11,12-epoxy-5,8,14-eicosatrienoic acid | Eph receptor B4 | Mus musculus |
| 2 | This effect and the activation of the EphB4 promoter were mediated by the phosphatidylinositol-3-kinase (P13-K)/Akt pathway and sensitive to the P13-K inhibitor LY 294002 as well as to simultaneous transfection with dominant-negative Akt. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | Eph receptor B4 | Mus musculus |
| 3 | 11,12-EET treatment also increased EphB4 expression in isolated mouse mesenteric arteries as well as in the vessels that developed in 11,12-EET-impregnated Matrigel plugs. | 11,12-epoxy-5,8,14-eicosatrienoic acid | Eph receptor B4 | Mus musculus |
| 4 | Moreover, the CYP2C9-stimulated formation of capillary-like structures in a modified spheroid assay was markedly attenuated by EphB4 downregulation (antisense oligonucleotides). | Oligonucleotides | Eph receptor B4 | Mus musculus |