PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18340006-1 2008 OBJECTIVE: Cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) are known to stimulate angiogenesis, but the mechanisms involved are incompletely understood. epoxyeicosatrienoic acids 53-78 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 11-26 18340006-1 2008 OBJECTIVE: Cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) are known to stimulate angiogenesis, but the mechanisms involved are incompletely understood. epoxyeicosatrienoic acids 53-78 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 28-31 18340006-1 2008 OBJECTIVE: Cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) are known to stimulate angiogenesis, but the mechanisms involved are incompletely understood. eets 80-84 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 11-26 18340006-1 2008 OBJECTIVE: Cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) are known to stimulate angiogenesis, but the mechanisms involved are incompletely understood. eets 80-84 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 28-31 18340006-3 2008 METHODS AND RESULTS: CYP2C9 overexpression as well as stimulation with 11,12-EET (up to 48 hours) time-dependently increased EphB4 expression in endothelial cells. 11,12-epoxy-5,8,14-eicosatrienoic acid 71-80 Eph receptor B4 Mus musculus 125-130 18340006-4 2008 This effect and the activation of the EphB4 promoter were mediated by the phosphatidylinositol-3-kinase (P13-K)/Akt pathway and sensitive to the P13-K inhibitor LY 294002 as well as to simultaneous transfection with dominant-negative Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 161-170 Eph receptor B4 Mus musculus 38-43 18340006-4 2008 This effect and the activation of the EphB4 promoter were mediated by the phosphatidylinositol-3-kinase (P13-K)/Akt pathway and sensitive to the P13-K inhibitor LY 294002 as well as to simultaneous transfection with dominant-negative Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 161-170 thymoma viral proto-oncogene 1 Mus musculus 234-237 18340006-5 2008 11,12-EET treatment also increased EphB4 expression in isolated mouse mesenteric arteries as well as in the vessels that developed in 11,12-EET-impregnated Matrigel plugs. 11,12-epoxy-5,8,14-eicosatrienoic acid 0-9 Eph receptor B4 Mus musculus 35-40 18340006-6 2008 Moreover, the CYP2C9-stimulated formation of capillary-like structures in a modified spheroid assay was markedly attenuated by EphB4 downregulation (antisense oligonucleotides). Oligonucleotides 159-175 Eph receptor B4 Mus musculus 127-132