Title : Characterization of in vivo and in vitro electrophysiological and antiarrhythmic effects of a novel IKACh blocker, NIP-151: a comparison with an IKr-blocker dofetilide.

Pub. Date : 2008 Feb

PMID : 18287884






1 Functional Relationships(s)
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1 NIP-151 potently inhibited acetylcholine-activated K current (IKACh) with an IC50, with 1.6 nM in HEK293 cells expressing the GIRK1/4 channel, but it had little effect on IKr (IC50 = 57.6 microM). Acetylcholine potassium inwardly rectifying channel subfamily J member 3 Homo sapiens