Pub. Date : 1991 Mar
PMID : 1825502
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of endogenously derived leukotrienes in the regulation of lysosomal enzyme expression in macrophages exposed to beta 1,3-glucan. | Leukotrienes | hemoglobin, beta adult major chain | Mus musculus |
| 2 | The expression of the lysosomal enzyme hexosaminidase has been shown to be stimulated by the exposure of mouse macrophages to beta 1,3-glucan, a particulate component of yeast cell walls and zymosan particles. | Zymosan | hemoglobin, beta adult major chain | Mus musculus |
| 3 | Exposure of mouse peritoneal macrophages to particulate beta 1,3-glucan (100 micrograms/ml) was also found to stimulate the production of eicosanoids from both the cyclooxygenase (prostaglandin E2) and 5"-lipoxygenase (leukotriene C4) pathways. | Eicosanoids | hemoglobin, beta adult major chain | Mus musculus |
| 4 | Exposure of mouse peritoneal macrophages to particulate beta 1,3-glucan (100 micrograms/ml) was also found to stimulate the production of eicosanoids from both the cyclooxygenase (prostaglandin E2) and 5"-lipoxygenase (leukotriene C4) pathways. | Dinoprostone | hemoglobin, beta adult major chain | Mus musculus |
| 5 | Exposure of mouse peritoneal macrophages to particulate beta 1,3-glucan (100 micrograms/ml) was also found to stimulate the production of eicosanoids from both the cyclooxygenase (prostaglandin E2) and 5"-lipoxygenase (leukotriene C4) pathways. | Leukotriene C4 | hemoglobin, beta adult major chain | Mus musculus |
| 6 | Collectively these data suggest that the leukotriene products of the 5"-lipoxygenase pathway, LTC4 and LTB4, regulate the expression of lysosomal enzymes by apparently priming macrophages, thereby increasing their sensitivity to triggering agents such as beta 1,3-glucan. | Leukotrienes | hemoglobin, beta adult major chain | Mus musculus |