Title : Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.

Pub. Date : 2008 Apr

PMID : 18212100






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity. alisporivir FKBP prolyl isomerase 1B Homo sapiens
2 For three cyclosporines, the inhibitory potential against PPIase activity was quantitatively correlated with that against human immunodeficiency virus type 1 (HIV-1) replication. Cyclosporins FKBP prolyl isomerase 1B Homo sapiens