Pub. Date : 2008 Mar
PMID : 18079277
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine. | Ranolazine | sodium voltage-gated channel alpha subunit 9 | Homo sapiens |
| 2 | Use-dependent block of Na(+) channel isoforms by ranolazine during repetitive pulses (+50 mV/10 ms at 5 Hz) was strong at 100 microM, up to 77% peak current reduction for Nav1.4, 67% for Nav1.5, and 83% for Nav1.7. | Ranolazine | sodium voltage-gated channel alpha subunit 9 | Homo sapiens |
| 3 | In addition, we found conspicuous time-dependent block of inactivation-deficient Nav1.4, Nav1.5, and Nav1.7 Na(+) currents by ranolazine with estimated IC(50) values of 2.4, 6.2, and 1.7 microM, respectively. | Ranolazine | sodium voltage-gated channel alpha subunit 9 | Homo sapiens |
| 4 | On- and off-rates of ranolazine were 8.2 microM(-1) s(-1) and 22 s(-1), respectively, for Nav1.4 open channels and 7.1 microM(-1) s(-1) and 14 s(-1), respectively, for Nav1.7 counterparts. | Ranolazine | sodium voltage-gated channel alpha subunit 9 | Homo sapiens |