Title : Sirolimus ameliorates the enhanced expression of metalloproteinases in a rat model of autosomal dominant polycystic kidney disease.

Pub. Date : 2008 Mar

PMID : 18042615






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Sirolimus treatment leads to decreased protein expression of MMP-2 and MMP-14 in Cy/+, whereas MMP-2 and MMP-14 mRNA levels and TIMP-2 protein levels were not affected by sirolimus. Sirolimus matrix metallopeptidase 14 Rattus norvegicus
2 Sirolimus treatment was associated with a marked improvement of MMP-2 and MMP-14 overexpression, and this correlated also with less matrix and TBM alterations and milder cystic disease. Sirolimus matrix metallopeptidase 14 Rattus norvegicus