Title : Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.

Pub. Date : 2008 Feb 1

PMID : 18021073






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have previously identified a feedback-control mechanism by which p38alpha MAPK down-regulates TAK1 and showed that p38alpha MAPK phosphorylates TAB1 at Ser(423) and Thr(431). Threonine mitogen-activated protein kinase kinase kinase 7 Homo sapiens
2 Studies using TAB1(-/-) MEFs indicate important roles for TAB1 in recruiting p38alpha MAPK to the TAK1 complex for the phosphorylation of TAB3 at Ser(60) and Thr(404) and in inhibiting the dephosphorylation of TAB3 at Ser(506). Serine mitogen-activated protein kinase kinase kinase 7 Homo sapiens
3 Studies using TAB1(-/-) MEFs indicate important roles for TAB1 in recruiting p38alpha MAPK to the TAK1 complex for the phosphorylation of TAB3 at Ser(60) and Thr(404) and in inhibiting the dephosphorylation of TAB3 at Ser(506). Threonine mitogen-activated protein kinase kinase kinase 7 Homo sapiens
4 Studies using TAB1(-/-) MEFs indicate important roles for TAB1 in recruiting p38alpha MAPK to the TAK1 complex for the phosphorylation of TAB3 at Ser(60) and Thr(404) and in inhibiting the dephosphorylation of TAB3 at Ser(506). Serine mitogen-activated protein kinase kinase kinase 7 Homo sapiens