Pub. Date : 2007 Nov 28
PMID : 17935702
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Abeta(1-42)-evoked dopamine release was sensitive to antagonists of alpha7 nicotinic receptors and was absent in mice harboring a null mutation for the alpha7 nicotinic subunit, but was intact in mice harboring a null mutation for the beta2 nicotinic subunit. | Dopamine | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 2 | In the present study, soluble Abeta was perfused into mouse prefrontal cortex and the effect on the release of dopamine outflow via microdialysis was assessed. | Dopamine | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 3 | In the presence of tetrodotoxin, Abeta(1-42) at 100 nM evoked the release of dopamine to approximately 170% of basal levels. | Tetrodotoxin | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 4 | In the presence of tetrodotoxin, Abeta(1-42) at 100 nM evoked the release of dopamine to approximately 170% of basal levels. | Dopamine | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 5 | In contrast, Abeta(1-42) at 1-10 pM caused a profound but slowly developing decrease in dopamine outflow. | Dopamine | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 6 | These results suggest that Abeta alters dopamine release in mouse prefrontal cortex, perhaps involving distinct targets as it accumulates during Alzheimer"s disease and leading to disruption of synaptic signaling. | Dopamine | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |