Pub. Date : 2007 Aug
PMID : 17699106
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. | Cisplatin | ceramide synthase 1 | Homo sapiens |
| 2 | Here, we show that the members of the sphingosine kinase (SphK1 and SphK2) and dihydroceramide synthase (LASS1/CerS1, LASS4/CerS4, and LASS5/CerS5) enzyme families each have a unique role in regulating sensitivity to cisplatin and other drugs. | Cisplatin | ceramide synthase 1 | Homo sapiens |
| 3 | Here, we show that the members of the sphingosine kinase (SphK1 and SphK2) and dihydroceramide synthase (LASS1/CerS1, LASS4/CerS4, and LASS5/CerS5) enzyme families each have a unique role in regulating sensitivity to cisplatin and other drugs. | Cisplatin | ceramide synthase 1 | Homo sapiens |
| 4 | Cisplatin was shown to cause a specific translocation of LASS1/CerS1, but not LASS4/CerS4 or LASS5/CerS5, from the endoplasmic reticulum (ER) to the Golgi apparatus. | Cisplatin | ceramide synthase 1 | Homo sapiens |
| 5 | Cisplatin was shown to cause a specific translocation of LASS1/CerS1, but not LASS4/CerS4 or LASS5/CerS5, from the endoplasmic reticulum (ER) to the Golgi apparatus. | Cisplatin | ceramide synthase 1 | Homo sapiens |
| 6 | Supporting the hypothesis that this translocation is mechanistically involved in the response to cisplatin, we showed that expression of SphK1, but not SphK2, abrogates both the increased cisplatin sensitivity in cells stably expressing LASS1/CerS and the translocation of the LASS1/CerS1. | Cisplatin | ceramide synthase 1 | Homo sapiens |