Pub. Date : 2008 May
PMID : 17638069
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A plant oxylipin, 12-oxo-phytodienoic acid, inhibits proliferation of human breast cancer cells by targeting cyclin D1. | 12-oxophytodienoic acid | cyclin D1 | Homo sapiens |
| 2 | In response to OPDA treatment, the human breast cancer cell lines exhibit a progressive decline in cyclin D1 expression, which is tightly associated with the accumulation of hypophosphorylated form of the retinoblastoma protein (Rb) and G1 arrest. | 12-oxophytodienoic acid | cyclin D1 | Homo sapiens |
| 3 | The proteasome inhibitor MG132 blocks OPDA-mediated decrease in cyclin D1. | 12-oxophytodienoic acid | cyclin D1 | Homo sapiens |
| 4 | In addition, the overexpression of T286A, a cyclin D1 mutant which is refractory to phosphorylation by GSK3beta and proteosomal degradation, is resistant to OPDA-mediated Rb dephosphorylation as well as G(1) cell cycle arrest. | 12-oxophytodienoic acid | cyclin D1 | Homo sapiens |
| 5 | Thus, our results demonstrate that degradation of cyclin D1 protein is a key event in OPDA induced growth inhibition in breast cancer cells. | 12-oxophytodienoic acid | cyclin D1 | Homo sapiens |