PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17638069-0	2008	A plant oxylipin, 12-oxo-phytodienoic acid, inhibits proliferation of human breast cancer cells by targeting cyclin D1.	12-oxophytodienoic acid	18-42	cyclin D1	Homo sapiens	109-118	
17638069-4	2008	In response to OPDA treatment, the human breast cancer cell lines exhibit a progressive decline in cyclin D1 expression, which is tightly associated with the accumulation of hypophosphorylated form of the retinoblastoma protein (Rb) and G1 arrest.	12-oxophytodienoic acid	15-19	cyclin D1	Homo sapiens	99-108	
17638069-6	2008	The proteasome inhibitor MG132 blocks OPDA-mediated decrease in cyclin D1.	12-oxophytodienoic acid	38-42	cyclin D1	Homo sapiens	64-73	
17638069-7	2008	In addition, the overexpression of T286A, a cyclin D1 mutant which is refractory to phosphorylation by GSK3beta and proteosomal degradation, is resistant to OPDA-mediated Rb dephosphorylation as well as G(1) cell cycle arrest.	12-oxophytodienoic acid	157-161	cyclin D1	Homo sapiens	44-53	
17638069-8	2008	Thus, our results demonstrate that degradation of cyclin D1 protein is a key event in OPDA induced growth inhibition in breast cancer cells.	12-oxophytodienoic acid	86-90	cyclin D1	Homo sapiens	50-59