Title : Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells.

Pub. Date : 2007 Oct

PMID : 17625602






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, we were able to increase the expression levels of MICA and MICB on leukemic cell lines and patients" leukemic cells by treatment with trichostatin A (TsA), a histone deacetylase (HDAC) inhibitor. trichostatin A MHC class I polypeptide-related sequence B Homo sapiens
2 In this study, we were able to increase the expression levels of MICA and MICB on leukemic cell lines and patients" leukemic cells by treatment with trichostatin A (TsA), a histone deacetylase (HDAC) inhibitor. trichostatin A MHC class I polypeptide-related sequence B Homo sapiens
3 Chromatin immunoprecipitation (ChIP) assays revealed that treatment with TsA resulted in increased acetylation of histone H3 and decreased association with HDAC1 at the promoters of MICA and MICB. trichostatin A MHC class I polypeptide-related sequence B Homo sapiens
4 Intriguingly, upregulation of MICA and MICB by treatment with TsA led to enhancement of the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells. trichostatin A MHC class I polypeptide-related sequence B Homo sapiens