Pub. Date : 2007 Oct
PMID : 17625103
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Gemfibrozil consistently inhibited the expression and DNA-binding activity of T-bet, a key regulator of interferon-gamma (IFN-gamma) expression and stimulated the expression and DNA-binding activity of GATA3, a key regulator of IL-4. | Gemfibrozil | T-box 21 | Mus musculus |
2 | The histological and immunohistochemical analyses also demonstrate the inhibitory effect of gemfibrozil on the invasion of T-bet-positive T cells into the spinal cord of EAE mice. | Gemfibrozil | T-box 21 | Mus musculus |
3 | Furthermore, we demonstrate that the differential effect of gemfibrozil on the expression of T-bet and GATA3 was due to its inhibitory effect on NO production. | Gemfibrozil | T-box 21 | Mus musculus |