Title : Altered renin release from isolated superfused rat glomeruli in DOCA-salt hypertensive rats.

Pub. Date : 1991

PMID : 1760888






5 Functional Relationships(s)
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1 Altered renin release from isolated superfused rat glomeruli in DOCA-salt hypertensive rats. Desoxycorticosterone Acetate renin Rattus norvegicus
2 The present study was designed to clarify the role of calcium in suppressed renin release in DOCA-salt hypertension. Desoxycorticosterone Acetate renin Rattus norvegicus
3 Basal levels of renin release were lower in the DOCA-salt hypertensive rats (1.16 +/- 0.27 ng/ATI/hr/hr/10(4) glomeruli, mean +/- SEM, n = 8) than in the control rats (1.92 +/- 0.18, p less than 0.01, n = 8). Desoxycorticosterone Acetate renin Rattus norvegicus
4 Perfusion with a calcium free solution containing EGTA and A23187 stimulated renin release in the DOCA-salt hypertensive and control rats. Desoxycorticosterone Acetate renin Rattus norvegicus
5 The maximum levels of renin release during the perfusion in DOCA-salt hypertensive rats (1.79 +/- 0.17, n = 8) were lower than those in control rats (10.60 +/- 1.85, p less than 0.01, n = 8). Desoxycorticosterone Acetate renin Rattus norvegicus