Pub. Date : 1992 Mar
PMID : 1740713
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A muscarinic receptor radioligand, carbon-11-(+)-2 alpha-tropanyl benzilate ([11C]TRB), has been prepared through N-[11C]methylation of N-desmethyl TRB, and evaluated in rodents and primates. | carbon-11-(+)-2 alpha-tropanyl benzilate | T cell receptor beta locus | Homo sapiens |
| 2 | A muscarinic receptor radioligand, carbon-11-(+)-2 alpha-tropanyl benzilate ([11C]TRB), has been prepared through N-[11C]methylation of N-desmethyl TRB, and evaluated in rodents and primates. | carbon-11-(+)-2 alpha-tropanyl benzilate | T cell receptor beta locus | Homo sapiens |
| 3 | A muscarinic receptor radioligand, carbon-11-(+)-2 alpha-tropanyl benzilate ([11C]TRB), has been prepared through N-[11C]methylation of N-desmethyl TRB, and evaluated in rodents and primates. | Carbon-11 | T cell receptor beta locus | Homo sapiens |
| 4 | A muscarinic receptor radioligand, carbon-11-(+)-2 alpha-tropanyl benzilate ([11C]TRB), has been prepared through N-[11C]methylation of N-desmethyl TRB, and evaluated in rodents and primates. | Carbon-11 | T cell receptor beta locus | Homo sapiens |
| 5 | Comparisons with [11C]scopolamine in rats showed 2-6 times greater brain uptake of [11C] TRB. | Carbon-11 | T cell receptor beta locus | Homo sapiens |
| 6 | Comparisons with [11C]scopolamine in rats showed 2-6 times greater brain uptake of [11C] TRB. | Scopolamine | T cell receptor beta locus | Homo sapiens |
| 7 | Highly specific and saturable binding of [11C]TRB in the striatum and cortex was demonstrated by greater than 85% blockade of uptake following QNB or scopolamine pretreatment. | Quinuclidinyl Benzilate | T cell receptor beta locus | Homo sapiens |
| 8 | Highly specific and saturable binding of [11C]TRB in the striatum and cortex was demonstrated by greater than 85% blockade of uptake following QNB or scopolamine pretreatment. | Scopolamine | T cell receptor beta locus | Homo sapiens |
| 9 | TLC analysis of rat tissues showed the absence of 11C-metabolites in brain and heart, and a rapid solid phase C-18 Sep-Pak method found that unmetabolized plasma [11C]TRB in monkeys fell from 81% at 5 min to 48% at 80 min. | Carbon-11 | T cell receptor beta locus | Homo sapiens |