Pub. Date : 2006
PMID : 17314493
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet. | Bleomycin | T-box 21 | Mus musculus |
| 2 | Bleomycin-induced early mast cells and eosinophil accumulation, and eosinophil degranulation, in the lesional tissue were greater in T-bet(-/-) mice than in wild-type control mice. | Bleomycin | T-box 21 | Mus musculus |
| 3 | These results demonstrate that in mice lacking T-bet bleomycin induced exaggerated skin fibrosis, suggesting that T-bet has an important physiologic role in regulation of tissue repair by promoting Th1 immune responses that prevent excessive ECM accumulation. | Bleomycin | T-box 21 | Mus musculus |
| 4 | These results demonstrate that in mice lacking T-bet bleomycin induced exaggerated skin fibrosis, suggesting that T-bet has an important physiologic role in regulation of tissue repair by promoting Th1 immune responses that prevent excessive ECM accumulation. | Bleomycin | T-box 21 | Mus musculus |