Pub. Date : 1991 Aug
PMID : 1715015
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Selective induction of cytochrome P450e by kepone (chlordecone) in primary cultures of adult rat hepatocytes. | Chlordecone | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 2 | Selective induction of cytochrome P450e by kepone (chlordecone) in primary cultures of adult rat hepatocytes. | Chlordecone | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 3 | Kepone also resembled phenobarbital in these experiments, in that there were dose-dependent increases in the amounts of hepatocellular P450p, P450pcn2, P450PB-1, P450f, and NADPH-cytochrome P450 oxidoreductase mRNAs. | Chlordecone | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 4 | Kepone also resembled phenobarbital in these experiments, in that there were dose-dependent increases in the amounts of hepatocellular P450p, P450pcn2, P450PB-1, P450f, and NADPH-cytochrome P450 oxidoreductase mRNAs. | Chlordecone | cytochrome P450, family 2, subfamily c, polypeptide 12 | Rattus norvegicus |
| 5 | Kepone also resembled phenobarbital in these experiments, in that there were dose-dependent increases in the amounts of hepatocellular P450p, P450pcn2, P450PB-1, P450f, and NADPH-cytochrome P450 oxidoreductase mRNAs. | Chlordecone | cytochrome P450, family 2, subfamily c, polypeptide 7 | Rattus norvegicus |
| 6 | However, in the same kepone-treated cells, P450b mRNA or P450b immunoreactive protein was induced only slightly, if at all. | Chlordecone | cytochrome P450, family 2, subfamily b, polypeptide 1 | Rattus norvegicus |
| 7 | However, in the same kepone-treated cells, P450b mRNA or P450b immunoreactive protein was induced only slightly, if at all. | Chlordecone | cytochrome P450, family 2, subfamily b, polypeptide 1 | Rattus norvegicus |
| 8 | Selective induction of P450e by kepone in the hepatocyte cultures, the first pharmacologic dissociation of the induction of P450b and P450e mRNAs and proteins, was not apparent in kepone-treated rats, where both P450b and P450e mRNAs were increased to equivalent extents. | Chlordecone | cytochrome P450, family 2, subfamily b, polypeptide 1 | Rattus norvegicus |
| 9 | Selective induction of P450e by kepone in the hepatocyte cultures, the first pharmacologic dissociation of the induction of P450b and P450e mRNAs and proteins, was not apparent in kepone-treated rats, where both P450b and P450e mRNAs were increased to equivalent extents. | Chlordecone | cytochrome P450, family 2, subfamily b, polypeptide 1 | Rattus norvegicus |