Title : Dexamethasone selectively modulates basal and lipopolysaccharide-induced metalloproteinase and tissue inhibitor of metalloproteinase production by human alveolar macrophages.

Pub. Date : 1991 Apr 15

PMID : 1707919






2 Functional Relationships(s)
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1 We found that dexamethasone selectively and coordinately inhibited expression of the following human metalloproteinases: interstitial collagenase, stromelysin, and the 92-kDa type IV collagenase, as well as TIMP. Dexamethasone TIMP metallopeptidase inhibitor 1 Homo sapiens
2 Both basal and LPS-stimulated cells exhibited similar degrees of inhibition, with greater than 50% decrease in secretion of all enzymes and TIMP observed at dexamethasone concentrations of greater than or equal to 10(-8) M in serum-containing medium. Dexamethasone TIMP metallopeptidase inhibitor 1 Homo sapiens