Title : Protection from chlordecone-amplified carbon tetrachloride toxicity by cyanidanol: regeneration studies.

Pub. Date : 1991 Mar 15

PMID : 1706540






4 Functional Relationships(s)
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1 Previous work has shown that chlordecone (CD)-amplified CCl4 hepatotoxicity and lethality can be mitigated by pretreatment with cyanidanol. Chlordecone C-C motif chemokine ligand 4 Rattus norvegicus
2 Previous work has shown that chlordecone (CD)-amplified CCl4 hepatotoxicity and lethality can be mitigated by pretreatment with cyanidanol. Chlordecone C-C motif chemokine ligand 4 Rattus norvegicus
3 These studies also revealed that stimulated hepatocellular regeneration might play an important role in the cyanidanol protection of CD-amplified CCl4 toxicity. Chlordecone C-C motif chemokine ligand 4 Rattus norvegicus
4 Challenge by the same dose of CCl4 (100 microliters/kg) to CD-pretreated rats not protected by cyanidanol failed to cause any increase in [3H]thymidine incorporation up to 36 hr and resulted in animal death starting at 36 hr. Chlordecone C-C motif chemokine ligand 4 Rattus norvegicus