Title : N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth.

Pub. Date : 2007 Jan

PMID : 17060446






2 Functional Relationships(s)
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1 Using brain lysates from PTPsigma knockout mice, in combination with substrate trapping, we identified a hyper-tyrosine-phosphorylated protein of approximately 120 kDa in the knockout animals (relative to sibling controls), which was identified by mass spectrometry and immunoblotting as N-cadherin. Tyrosine protein tyrosine phosphatase, receptor type, S Mus musculus
2 These results suggest that the elevated tyrosine phosphorylation of N-cadherin in the PTPsigma(-/-) mice likely disrupted N-cadherin function, resulting in accelerated DRG nerve growth. Tyrosine protein tyrosine phosphatase, receptor type, S Mus musculus