Title : Novel therapy for heart failure and exercise-induced ventricular tachycardia based on 'fixing' the leak in ryanodine receptors.

Pub. Date : 2006

PMID : 17019810






1 Functional Relationships(s)
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1 We and others have identified a class of small molecules derived from 1,4-benzothiazepines, that enhance the binding affinity of calstabin 2 for RyR2 and reduce the diastolic SR Ca2+ leak, even when the channel is PKA hyperphosphorylated. 1,4-benzothiazepines FKBP prolyl isomerase 1B Homo sapiens