Pub. Date : 2006 Oct 1
PMID : 16982895
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We determined the crystal structure at 2.6-A resolution of mouse CD1d bound to a synthetic dipalmitoyl-PIM2. | Phosphatidic Acids | proviral integration site 2 | Mus musculus |
| 2 | Natural PIM2, which differs in its fatty acid composition is a biosynthetic precursor of PIM4, PIM6, lipomannan, and lipoarabinomannan. | Fatty Acids | proviral integration site 2 | Mus musculus |
| 3 | Natural PIM2, which differs in its fatty acid composition is a biosynthetic precursor of PIM4, PIM6, lipomannan, and lipoarabinomannan. | lipomannan | proviral integration site 2 | Mus musculus |
| 4 | Natural PIM2, which differs in its fatty acid composition is a biosynthetic precursor of PIM4, PIM6, lipomannan, and lipoarabinomannan. | lipoarabinomannan | proviral integration site 2 | Mus musculus |
| 5 | The PIM2 headgroup (inositol-dimannoside) is the most complex to date among all the crystallized CD1d ligands and is remarkably ordered in the CD1d binding groove. | inositol-dimannoside | proviral integration site 2 | Mus musculus |
| 6 | A specific hydrogen-bonding network between PIM2 and CD1d orients the headgroup in the center of the binding groove and above the A" pocket. | Hydrogen | proviral integration site 2 | Mus musculus |
| 7 | The additional two mannoses in PIM4, relative to PIM2, are located at the distal 6" carbon of the alpha1-alpha6-linked mannose and would project away from the CD1d binding groove for interaction with the TCR. | Carbon | proviral integration site 2 | Mus musculus |
| 8 | Compared with other CD1d-sphingolipid structures, PIM2 has an increased number of polar interactions between its headgroup and CD1, but reduced specificity for the diacylglycerol backbone. | Sphingolipids | proviral integration site 2 | Mus musculus |
| 9 | Compared with other CD1d-sphingolipid structures, PIM2 has an increased number of polar interactions between its headgroup and CD1, but reduced specificity for the diacylglycerol backbone. | Diglycerides | proviral integration site 2 | Mus musculus |