Pub. Date : 1990 Aug 15
PMID : 1696822
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Altered hepatic energy status in chlordecone (Kepone)-potentiated CCl4 hepatotoxicity. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 2 | Altered hepatic energy status in chlordecone (Kepone)-potentiated CCl4 hepatotoxicity. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 3 | Previous studies have demonstrated that increased intracellular calcium, depletion of glycogen, and suppressed hepatocellular division resulting in progression of hepatic lesion without recovery are associated with chlordecone (CD)-potentiated CCl4 hepatotoxicity. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 4 | Previous studies have demonstrated that increased intracellular calcium, depletion of glycogen, and suppressed hepatocellular division resulting in progression of hepatic lesion without recovery are associated with chlordecone (CD)-potentiated CCl4 hepatotoxicity. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 5 | However, CCl4 administration to CD pretreated rats resulted in significantly decreased hepatic ATP content as early as 1 hr (36%), and this decrease was irreversibly progressive with time (81% at 6 hr). | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 6 | These findings indicate that CCl4 administration to CD but not to PB or mirex pretreated rats results in a severely compromised energy status of the liver. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 7 | The progressive and early depletion of liver ATP and the inhibition of Mg2(+)-ATPase in CD + CCl4 treated rats indicate the association of compromised energy status with altered Ca2+ homeostasis, depletion of glycogen, and suppressed cell division in CD-potentiated CCl4 toxicity. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |