Title : Pravastatin reduces lung metastasis of rat hepatocellular carcinoma via a coordinated decrease of MMP expression and activity.

Pub. Date : 2007 Jan

PMID : 16935385






1 Functional Relationships(s)
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1 Pravastatin decreased liver matrix metalloproteinase (MMP)-9 activity and mostly suppressed MMP-2 activation (p<0.004), likely because it decreased expression of MMP-14 and tissue inhibitor of matrix metalloproteinases-2 (p<0.01), required for MMP-2 activation. Pravastatin matrix metallopeptidase 14 Rattus norvegicus