Title : Quantitative relation between intermolecular and intramolecular binding of pro-rich peptides to SH3 domains.

Pub. Date : 2006 Nov 1

PMID : 16891373






1 Functional Relationships(s)
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1 Here we analyze three usages of flexible linkers: 1), intramolecular binding of proline-rich peptides (PRPs) to SH3 domains for kinase regulation; 2), intramolecular binding of PRP for increasing the folding stability of SH3 domains; and 3), covalent linking of PRPs and other ligands for high-affinity bivalent binding. Proline caspase recruitment domain family member 14 Homo sapiens