Title : Inducible and reversible suppression of Npm1 gene expression using stably integrated small interfering RNA vector in mouse embryonic stem cells.

Pub. Date : 2006 Sep 8

PMID : 16870143






2 Functional Relationships(s)
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1 Here, we present the first application of the Tc-inducible, stably integrated plasmid-based siRNA system in mouse ES cells to down-regulate expression of Npm1, an essential gene for embryonic development. Tetracycline nucleophosmin 1 Mus musculus
2 Our data show that the knock-down of Npm1 expression by this siRNA system was not only highly efficient, but also Tc- dose- and induction time-dependent. Tetracycline nucleophosmin 1 Mus musculus