Title : Ca2+-dependent regulation of calcitonin gene expression by the transcriptional repressor DREAM.

Pub. Date : 2006 Oct

PMID : 16840549






5 Functional Relationships(s)
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1 Together, these results suggest that DREAM plays an important role in human CT gene expression in a Ca(2+)- and cAMP-dependent manner. Cyclic AMP potassium voltage-gated channel interacting protein 3 Homo sapiens
2 In contrast to the wild type, overexpression of the mutant DREAM inhibited the increase in CT secretion induced by a calcium ionophore. Calcium potassium voltage-gated channel interacting protein 3 Homo sapiens
3 The addition of forskolin to increase cAMP activated the CT promoter, probably by the interaction of DREAM with cAMP-responsive element binding proteins, independent on the activation by Ca(2+). Colforsin potassium voltage-gated channel interacting protein 3 Homo sapiens
4 The addition of forskolin to increase cAMP activated the CT promoter, probably by the interaction of DREAM with cAMP-responsive element binding proteins, independent on the activation by Ca(2+). Cyclic AMP potassium voltage-gated channel interacting protein 3 Homo sapiens
5 The addition of forskolin to increase cAMP activated the CT promoter, probably by the interaction of DREAM with cAMP-responsive element binding proteins, independent on the activation by Ca(2+). Cyclic AMP potassium voltage-gated channel interacting protein 3 Homo sapiens