Title : Altered expression of Fas/Fas ligand/caspase 8 and membrane type 1-matrix metalloproteinase in atretic follicles within dehydroepiandrosterone-induced polycystic ovaries in rats.

Pub. Date : 2006 Sep

PMID : 16820958






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 To further investigate the process of follicular atresia, we compared ovarian expression and localization of Fas, Fas ligand (FasL), casapse-8 and membrane-type1 matrix metalloproteinase (MT1-MMP) in rats treated with dehydroepiandrosterone (DHEA) as a model of PCOS, and in control rats. Dehydroepiandrosterone matrix metallopeptidase 14 Rattus norvegicus
2 To further investigate the process of follicular atresia, we compared ovarian expression and localization of Fas, Fas ligand (FasL), casapse-8 and membrane-type1 matrix metalloproteinase (MT1-MMP) in rats treated with dehydroepiandrosterone (DHEA) as a model of PCOS, and in control rats. Dehydroepiandrosterone matrix metallopeptidase 14 Rattus norvegicus
3 Our results suggest that under the PCOS-like conditions induced by DHEA, the Fas/FasL/Caspase-8 (death receptor dependent) pathway is pivotal for follicular atresia, and that increased levels of MT1-MMP likely play an important role in tissue remodeling during structural luteolysis. Dehydroepiandrosterone matrix metallopeptidase 14 Rattus norvegicus