Title : Effect of vitamin A on the CD44 expression in the small intestine of rats with obstructive jaundice.

Pub. Date : 2006

PMID : 16804311






6 Functional Relationships(s)
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1 Effect of vitamin A on the CD44 expression in the small intestine of rats with obstructive jaundice. Vitamin A CD44 molecule (Indian blood group) Rattus norvegicus
2 HYPOTHESIS: In this study, the influence of obstructive jaundice on the CD44 expression in the rat small intestine and the alterations of this CD44 expression by vitamin A given intraperitoneally (200 IU/g/day) are evaluated. Vitamin A CD44 molecule (Indian blood group) Rattus norvegicus
3 When groups A and B were compared with group C (obstructive jaundice + saline) animals, the number of cells expressing surface CD44 was significantly decreased in both jejunum and ileum in group C. The difference between sham groups (A and B) and group C was found to be significant (p < 0.05). Sodium Chloride CD44 molecule (Indian blood group) Rattus norvegicus
4 When group D (obstructive jaundice + vitamin A) was compared with group C (obstructive jaundice + saline), the number of cells expressing surface CD44 was significantly increased in jejunum and ileum in group D animals (p < 0.05), higher than in the sham groups (A and B). Vitamin A CD44 molecule (Indian blood group) Rattus norvegicus
5 When group D (obstructive jaundice + vitamin A) was compared with group C (obstructive jaundice + saline), the number of cells expressing surface CD44 was significantly increased in jejunum and ileum in group D animals (p < 0.05), higher than in the sham groups (A and B). Sodium Chloride CD44 molecule (Indian blood group) Rattus norvegicus
6 We found that daily intraperitoneal administration of vitamin A in rats with obstructive jaundice for 2 weeks significantly restored the impaired CD44 expression. Vitamin A CD44 molecule (Indian blood group) Rattus norvegicus