Title : Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.

Pub. Date : 2006 May 16

PMID : 16672364






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The 1,4-benzothiazepine JTV519, which increases the binding affinity of calstabin-2 for RyR2, inhibited the diastolic SR Ca2+ leak, monophasic action potential alternans and triggered arrhythmias. 1,4-Benzothiazepine FK506 binding protein 1b Mus musculus
2 The 1,4-benzothiazepine JTV519, which increases the binding affinity of calstabin-2 for RyR2, inhibited the diastolic SR Ca2+ leak, monophasic action potential alternans and triggered arrhythmias. K201 compound FK506 binding protein 1b Mus musculus