Pub. Date : 2006 Apr
PMID : 16533898
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TRPM7 channel is regulated by magnesium nucleotides via its kinase domain. | magnesium nucleotides | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 2 | TRPM7 is a Ca(2+)- and Mg(2+)-permeable cation channel that also contains a protein kinase domain. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 3 | While there is general consensus that the channel is inhibited by free intracellular Mg(2+), the functional roles of intracellular levels of Mg.ATP and the kinase domain in regulating TRPM7 channel activity have been discussed controversially. | Magnesium | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 4 | While there is general consensus that the channel is inhibited by free intracellular Mg(2+), the functional roles of intracellular levels of Mg.ATP and the kinase domain in regulating TRPM7 channel activity have been discussed controversially. | Adenosine Triphosphate | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 5 | We report here that physiological Mg.ATP concentrations can inhibit TRPM7 channels and strongly enhance the channel blocking efficacy of free Mg(2+). | Magnesium | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 6 | We report here that physiological Mg.ATP concentrations can inhibit TRPM7 channels and strongly enhance the channel blocking efficacy of free Mg(2+). | Adenosine Triphosphate | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 7 | Furthermore, nearly all Mg-nucleotides were able to inhibit TRPM7 activity to varying degrees with the following rank in potency: ATP > TTP > CTP > or = GTP > or = UTP > ITP approximately free Mg(2+) alone. | mg-nucleotides | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 8 | Furthermore, nearly all Mg-nucleotides were able to inhibit TRPM7 activity to varying degrees with the following rank in potency: ATP > TTP > CTP > or = GTP > or = UTP > ITP approximately free Mg(2+) alone. | Adenosine Triphosphate | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 9 | Furthermore, nearly all Mg-nucleotides were able to inhibit TRPM7 activity to varying degrees with the following rank in potency: ATP > TTP > CTP > or = GTP > or = UTP > ITP approximately free Mg(2+) alone. | Cytidine Triphosphate | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 10 | Furthermore, nearly all Mg-nucleotides were able to inhibit TRPM7 activity to varying degrees with the following rank in potency: ATP > TTP > CTP > or = GTP > or = UTP > ITP approximately free Mg(2+) alone. | Guanosine Triphosphate | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 11 | Furthermore, nearly all Mg-nucleotides were able to inhibit TRPM7 activity to varying degrees with the following rank in potency: ATP > TTP > CTP > or = GTP > or = UTP > ITP approximately free Mg(2+) alone. | Uridine Triphosphate | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 12 | Furthermore, nearly all Mg-nucleotides were able to inhibit TRPM7 activity to varying degrees with the following rank in potency: ATP > TTP > CTP > or = GTP > or = UTP > ITP approximately free Mg(2+) alone. | Inosine Triphosphate | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 13 | These nucleotides also enhanced TRPM7 inhibition by free Mg(2+), suggesting the presence of two interacting binding sites that jointly regulate TRPM7 channel activity. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 14 | These nucleotides also enhanced TRPM7 inhibition by free Mg(2+), suggesting the presence of two interacting binding sites that jointly regulate TRPM7 channel activity. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |