Title : Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells.

Pub. Date : 2006 Jun 22

PMID : 16532036






3 Functional Relationships(s)
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1 Furthermore, AKT phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) on Ser-83 was reduced by DPI and siNox4RNAs. Serine mitogen-activated protein kinase kinase kinase 5 Homo sapiens
2 Furthermore, AKT phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) on Ser-83 was reduced by DPI and siNox4RNAs. Serine mitogen-activated protein kinase kinase kinase 5 Homo sapiens
3 Taken together, these findings suggest that ROS generated by Nox4, at least in part, transmit cell survival signals through the AKT-ASK1 pathway in pancreatic cancer cells and their depletion leads to apoptosis. Reactive Oxygen Species mitogen-activated protein kinase kinase kinase 5 Homo sapiens