Title : EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing.

Pub. Date : 2006 Sep

PMID : 16478662






2 Functional Relationships(s)
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1 It has also been documented for the receptor-like protein tyrosine phosphatase PTP-LAR, induced by treating cells with the tumor promoter TPA or the calcium ionophor A23187. Tetradecanoylphorbol Acetate protein tyrosine phosphatase, receptor type, S Mus musculus
2 In contrast to TPA-induced shedding of PTP-LAR, EGFR-mediated cleavage did not require PKC-activity. Tetradecanoylphorbol Acetate protein tyrosine phosphatase, receptor type, S Mus musculus