Title : Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer.

Pub. Date : 2006 Jan

PMID : 16341243






1 Functional Relationships(s)
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1 Here we show that loss of the Von Hippel-Lindau tumor suppressor gene (VHL) sensitizes kidney cancer cells to the mTOR inhibitor CCI-779 in vitro and in mouse models. temsirolimus mechanistic target of rapamycin kinase Mus musculus